거타퍼챠 포인트 및 열가소성 근관충전 재료의 세포독성
Cytotoxicity of gutta-percha points and thermoplastic endodontic obturation materials
김정환, 송요한, 김지우, 이응범, 송호준, 박영준,
소속 상세정보
김정환 ( Kim Jung-Hwan ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
송요한 ( Song Yo-Han ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
김지우 ( Kim Ji-Woo ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
이응범 ( Lee Eung-Beom ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
송호준 ( Song Ho-June ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
박영준 ( Park Young-Jun ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
KMID : 0362220130400020095
Abstract
This study was purposed to evaluate the cytotoxicity of commercially available 3 types of prefabricated gutta-percha points and 8 types of thermoplastic endodontic obturation materials using MTT tests and agar overlay test.
On MTT test, the Obtura® showed significantly lower cell viability (16.3±0.8% vs. Control; p＜0.05), which is over four times lower than those of other tested materials (p＜0.05). The Diadent point®, Sure-endo point®, and Diadent Medium® showed rather higher cell viability compared to that of Control (p＜0.05).
On agar overlay test, Sure-endo Soft® and Sure-endo Hard® showed a lower cytotoxicity (decolorization index = 2) compared to other tested materials (decolorization index = 3), while all the tested materials ranked as ‘moderate cytotoxic’ (response index = 2/2 or 3/2).
From this study it is demonstrated that the endodontic obturation materials have various degrees of cytotoxicity, and further in vivo biocompatibility evaluation is needed.
키워드
Gutta-percha; thermoplastic materials; cytotoxicity; MTT; Agar overlay
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